Noninvasive recording of fast optical signals presumably reflecting neuronal activity is a challenging task because of a relatively low signal-to-noise ratio. To improve detection of those signals in rapid object recognition tasks, we used the independent component analysis (ICA) to reduce “global interference” (heartbeat and contribution of superficial layers). We recorded optical signals from the left prefrontal cortex in 10 right-handed participants with a continuous-wave instrument (DYNOT, NIRx, Brooklyn, NY). Visual stimuli were pictures of urban, landscape and seashore scenes with various vehicles as targets (target-to-non-target ratio 1:6) presented at ISI=166 ms or 250 ms. Subjects mentally counted targets. Data were filtered at 2–30 Hz and artifactual components were identified visually (for heartbeat) and using the ICA weight matrix (for superficial layers). Optical signals were restored from the ICA components with artifactual components removed and then averaged over target and non-target epochs. After ICA processing, the event-related response was detected in 70%–100% of subjects. The refined signal showed a significant decrease from baseline within 200–300 ms after targets and a slight increase after nontargets. The temporal profile of the optical signal corresponded well to the profile of a “differential ERP response”, the difference between targets and non-targets which peaks at 200 ms in similar object detection tasks. These results demonstrate that the detection of fast optical responses with continuous-wave instruments can be improved through the ICA method capable to remove noise, global interference and the activity of superficial layers. Fast optical signals may provide further information on brain processing during higherorder cognitive tasks such as rapid categorization of objects.