Randall L. Barbour et al. (1997)


In this report we consider the merits of optical methods for use as a nonionizing diagnostic imaging tool, in relation to current imaging methods, and WE discuss critical issues needing further development. Evidence of feasibility of provided by recovery of inclusions embedded in an anatomically accurate 3D map of breast derived from MRI data. In addition, progress toward developing a practical imaging system is given by description of a general-purpose imaging device. Also discussed is the potential for expanding the utility of optical methods by development of optical contrast agents sensitive to different metabolic states, and for extending the utility of optical methods beyond diagnosis to create new strategies for rational therapeutic intervention.